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plc g sh3 domain  (Cytoskeleton Inc)


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    Structured Review

    Cytoskeleton Inc plc g sh3 domain
    Upstream effectors; RhoGAsP, RhoGDIs, GEFs.
    Plc G Sh3 Domain, supplied by Cytoskeleton Inc, used in various techniques. Bioz Stars score: 95/100, based on 181 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/plc+g+sh3+domain/Rac1+Pull-down+Activation+Assay+Biochem+Kit/pmc07140047-52-25-37
    Average 95 stars, based on 181 article reviews
    plc g sh3 domain - by Bioz Stars, 2026-10
    95/100 stars

    Images

    1) Product Images from "Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis"

    Article Title: Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis

    Journal: Cancers

    doi: 10.3390/cancers12030665

    Upstream effectors; RhoGAsP, RhoGDIs, GEFs.
    Figure Legend Snippet: Upstream effectors; RhoGAsP, RhoGDIs, GEFs.

    Techniques Used: Activity Assay, Migration, Membrane, Binding Assay, Over Expression, Microarray, Activation Assay, Expressing, Adhesive, Mutagenesis, Genome Wide, Variant Assay, Blocking Assay, In Vivo

    Interacting partners and functional consequences.
    Figure Legend Snippet: Interacting partners and functional consequences.

    Techniques Used: Functional Assay, Membrane, Activity Assay, Activation Assay, Mutagenesis, Over Expression, Binding Assay, Migration, Translocation Assay, Expressing, Transduction, Scaffolding, Control, Sequencing, Extraction, Inhibition, Knockdown

    Related Articles

    Planar Chromatography:

    Article Title: Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis
    Article Snippet: PREX1 , Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 , Guanine-nucleotide exchange factors for Rac family small G proteins , Stimulation of cell migration [ , ]. , . .. PLCG1, PLC-gamma-1 , Phospholipase C Gamma 1 , Hydrolysis of phosphatidylinositol 4,5-bisphosphate to 1,4,5-trisphosphate (IP3) and diacylglycerol , Critical for EGF-induced Rac1 activation in vivo. PLC-g SH3 domain acts as a Rac1 guanine nucleotide exchange in vivo. Cytoskeleton remodeling and cell migration [ ]. , . .. RCC2 , Regulator of Chromosome Condensation 2 , Guanine exchange factor for RalA , Interacts with Switch regions. RCC2 inhibits GEF-mediated activation of Rac1, preventing formation of multiple protrusions. RCC2 interacts with and transfers Rac1-GDP to Coro1C. Depletion of Coro1C or RCC2 causes loss of cell polarity that results in shunting migration. RCC2 is a transcriptional target of TP53, it deactivates Rac1 and inhibits migration of colon cancer cells. Decreased expression in CRC associated with a good prognosis for patients with MSI-CRC, a poor prognosis for patients with MSS-CRC [ ]. , [ , ] .

    Activation Assay:

    Article Title: Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis
    Article Snippet: PREX1 , Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 , Guanine-nucleotide exchange factors for Rac family small G proteins , Stimulation of cell migration [ , ]. , . .. PLCG1, PLC-gamma-1 , Phospholipase C Gamma 1 , Hydrolysis of phosphatidylinositol 4,5-bisphosphate to 1,4,5-trisphosphate (IP3) and diacylglycerol , Critical for EGF-induced Rac1 activation in vivo. PLC-g SH3 domain acts as a Rac1 guanine nucleotide exchange in vivo. Cytoskeleton remodeling and cell migration [ ]. , . .. RCC2 , Regulator of Chromosome Condensation 2 , Guanine exchange factor for RalA , Interacts with Switch regions. RCC2 inhibits GEF-mediated activation of Rac1, preventing formation of multiple protrusions. RCC2 interacts with and transfers Rac1-GDP to Coro1C. Depletion of Coro1C or RCC2 causes loss of cell polarity that results in shunting migration. RCC2 is a transcriptional target of TP53, it deactivates Rac1 and inhibits migration of colon cancer cells. Decreased expression in CRC associated with a good prognosis for patients with MSI-CRC, a poor prognosis for patients with MSS-CRC [ ]. , [ , ] .

    In Vivo:

    Article Title: Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis
    Article Snippet: PREX1 , Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 , Guanine-nucleotide exchange factors for Rac family small G proteins , Stimulation of cell migration [ , ]. , . .. PLCG1, PLC-gamma-1 , Phospholipase C Gamma 1 , Hydrolysis of phosphatidylinositol 4,5-bisphosphate to 1,4,5-trisphosphate (IP3) and diacylglycerol , Critical for EGF-induced Rac1 activation in vivo. PLC-g SH3 domain acts as a Rac1 guanine nucleotide exchange in vivo. Cytoskeleton remodeling and cell migration [ ]. , . .. RCC2 , Regulator of Chromosome Condensation 2 , Guanine exchange factor for RalA , Interacts with Switch regions. RCC2 inhibits GEF-mediated activation of Rac1, preventing formation of multiple protrusions. RCC2 interacts with and transfers Rac1-GDP to Coro1C. Depletion of Coro1C or RCC2 causes loss of cell polarity that results in shunting migration. RCC2 is a transcriptional target of TP53, it deactivates Rac1 and inhibits migration of colon cancer cells. Decreased expression in CRC associated with a good prognosis for patients with MSI-CRC, a poor prognosis for patients with MSS-CRC [ ]. , [ , ] .

    Migration:

    Article Title: Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis
    Article Snippet: PREX1 , Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 , Guanine-nucleotide exchange factors for Rac family small G proteins , Stimulation of cell migration [ , ]. , . .. PLCG1, PLC-gamma-1 , Phospholipase C Gamma 1 , Hydrolysis of phosphatidylinositol 4,5-bisphosphate to 1,4,5-trisphosphate (IP3) and diacylglycerol , Critical for EGF-induced Rac1 activation in vivo. PLC-g SH3 domain acts as a Rac1 guanine nucleotide exchange in vivo. Cytoskeleton remodeling and cell migration [ ]. , . .. RCC2 , Regulator of Chromosome Condensation 2 , Guanine exchange factor for RalA , Interacts with Switch regions. RCC2 inhibits GEF-mediated activation of Rac1, preventing formation of multiple protrusions. RCC2 interacts with and transfers Rac1-GDP to Coro1C. Depletion of Coro1C or RCC2 causes loss of cell polarity that results in shunting migration. RCC2 is a transcriptional target of TP53, it deactivates Rac1 and inhibits migration of colon cancer cells. Decreased expression in CRC associated with a good prognosis for patients with MSI-CRC, a poor prognosis for patients with MSS-CRC [ ]. , [ , ] .



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    Image Search Results


    Upstream effectors; RhoGAsP, RhoGDIs, GEFs.

    Journal: Cancers

    Article Title: Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis

    doi: 10.3390/cancers12030665

    Figure Lengend Snippet: Upstream effectors; RhoGAsP, RhoGDIs, GEFs.

    Article Snippet: PLCG1, PLC-gamma-1 , Phospholipase C Gamma 1 , Hydrolysis of phosphatidylinositol 4,5-bisphosphate to 1,4,5-trisphosphate (IP3) and diacylglycerol , Critical for EGF-induced Rac1 activation in vivo. PLC-g SH3 domain acts as a Rac1 guanine nucleotide exchange in vivo. Cytoskeleton remodeling and cell migration [ ]. , .

    Techniques: Activity Assay, Migration, Membrane, Binding Assay, Over Expression, Microarray, Activation Assay, Expressing, Adhesive, Mutagenesis, Genome Wide, Variant Assay, Blocking Assay, In Vivo

    Interacting partners and functional consequences.

    Journal: Cancers

    Article Title: Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis

    doi: 10.3390/cancers12030665

    Figure Lengend Snippet: Interacting partners and functional consequences.

    Article Snippet: PLCG1, PLC-gamma-1 , Phospholipase C Gamma 1 , Hydrolysis of phosphatidylinositol 4,5-bisphosphate to 1,4,5-trisphosphate (IP3) and diacylglycerol , Critical for EGF-induced Rac1 activation in vivo. PLC-g SH3 domain acts as a Rac1 guanine nucleotide exchange in vivo. Cytoskeleton remodeling and cell migration [ ]. , .

    Techniques: Functional Assay, Membrane, Activity Assay, Activation Assay, Mutagenesis, Over Expression, Binding Assay, Migration, Translocation Assay, Expressing, Transduction, Scaffolding, Control, Sequencing, Extraction, Inhibition, Knockdown